Profhilo is a Hyaluronic Acid produced by an Italian company. It is available in Europe but not available in the United States. This is because it does not have FDA approval in America.

Hyaluronic Acid is nowadays the most commonly used Dermal Filler. It comes in many different forms and to put it very simply can be divided into:

  1. Hyaluronic Acid where the particles of Hyaluronic Acid are bonded together. If they were not bonded then the Hyaluronic Acid would be dissolved by the body within a few days. The bonding means that the filler can last from 9 to 18 months or even longer. This is the most commonly used type or Dermal Filler.
  2. Skin Boosters of which there are many different types. They have generally less bonding are therefore more flowable, but do not last long . They are injected just under the skin and have a temporary plumping affect. The main claim that is made for their use is that they stimulate the formation of healthy skin.
  3. The new kid on the block is Profhilo which has a patented new type of “bonding” allowing it to last longer in the body (about 30 days) but still be very fluid so that when injected just under the skin it can flow and spread evenly. It also has a higher concentration of Hyaluronic Acid than most of the standard fillers.

The main marketing claim for Profhilo is that overtime the presence of the Profhilo just under the skin surface will stimulate the production of a healthier skin (known as Biomodulation). Unfortunately, there is no strong scientific evidence to validate this, (this does not mean the claim is not true).

The 2016 scientific paper which is the main evidence for the use of Profhilo is entitled:

Efficacy and tolerance of an injectable medical device containing stable hybrid cooperative complexes of high- and low-molecular-weight hyaluronic acid: a monocentric 16 weeks open-label evaluation

The main problem I have with this evidence is that it was sponsored by the company that makes Profhilo.

Practical Details of Using Profhilo

It requires 10 separate injections just under the skin (5 each side of the face). These should be repeated 4 weeks later. The cost would be around £600. At present it looks as though this would need to be repeated every 6 months.

These are the pictures taken from the above scientific paper showing before and 8 weeks after treatment and I assume are the best pictures they could get.

I will let you judge if you think the improvement is worth the effort and expense.


My Personal Opinion

It is great that more and more people want to take care of themselves and this includes reversing or slowing down the facial ageing process.

As a practitioner I want my clients to get value for money and I know that when I use Botox/Azzalure or Dermal fillers all my clients will see a positive result lasting 4 to 6 months for Botox/Azzalure and lasting normally 12 to 18 months for Dermal fillers. In other words, you get a “Bang for your Buck”.

At present I am not convinced that you will get value for money over time with Profhilo but am keeping an open mind to see if any good evidence for its use comes out in the future.

Have you had Botox elsewhere and are thinking of changing clinics?

Are you thinking of trying Botox for the first time?

For a free and confidential consultation please:

Phone Dr Peter Lawson on 0790 30 777 03

or email

Or text Marnie Lawson on 07951 325 388

Or please complete our enquiry form

We are pleased to see Botox & Dermal Filler patients from; Hungerford, Thatcham, Chieveley, Hermitage, Marlborough, Andover, Reading and the surrounding Berkshire areas.

Dr Peter L. Lawson

BDS Dentistry (Wales)

FDS RCPS Dentistry (Glasgow)

M.Sc. Nutritional Medicine (Surrey University)

PG Dip. Skin Ageing and Aesthetic Medicine (Manchester University)

Marnie L. Lawson 

Dip ION  Nutritional Therapy

NEBDN   Dental Nurse

Facial Aesthetic Nurse