Profhilo

Profhilo is a Hyaluronic Acid produced by an Italian company. It is available in Europe. At the time of writing this it was not available in the United States and did not have FDA approval.

Hyaluronic Acid is nowadays the most commonly used Dermal Filler. It comes in many different forms and to put it very simply can be divided into:

Hyaluronic Acid where the particles of Hyaluronic Acid are bonded together. If they were not bonded then the Hyaluronic Acid would be dissolved by the body within a few days. The bonding means that the filler can last from 9 to 18 months or even longer. This is the most commonly used type or Dermal Filler.

Skin Boosters of which there are many different types. They have generally less bonding are therefore more flowable, but do not last long . They are injected just under the skin and have a temporary plumping affect. The main claim that is made for their use is that they stimulate the formation of healthy skin.

The main marketing claim for Profhilo is that overtime the presence of the Profhilo just under the skin surface will stimulate the production of a healthier skin (known as Biomodulation). Unfortunately, there is no strong scientific evidence to validate this, (this does not mean the claim is not true).

The 2016 scientific paper which is the main evidence for the use of Profhilo is entitled: “Efficacy and tolerance of an injectable medical device containing stable hybrid cooperative complexes of high- and low-molecular-weight hyaluronic acid: a monocentric 16 weeks open-label evaluation”

The main problem I have with this evidence is that it was sponsored by the company that makes Profhilo.

Practical Details of Using Profhilo

It requires 10 separate injections just under the skin (5 each side of the face). These should be repeated 4 weeks later. The cost would be around £600. At present it looks as though this would need to be repeated every 6 months.

These are the pictures taken from the above scientific paper showing before and 8 weeks after treatment and I assume are the best pictures they could get.

Due to the negative feedback, I have had from new patients that have had Profhilo treatment elsewhere before they came to see me I have decided not offer Profhilo as a treatment.

A  Before Profhilo treatment  B  After Profhilo treatment. I will let you judge if you think the improvement is worth the effort and expense.

My Personal Opinion

It is great that more and more people want to take care of themselves, and this includes reversing or slowing down the facial ageing process.

Polynucleotides

Polynucleotides are currently being heavily promoted in the aesthetics market for their purported benefits in skin regeneration and hydration. These substances are typically derived from salmon or trout DNA and are frequently recommended for under-eye treatments to address concerns such as dark circles, fine lines, and uneven skin texture.

A typical treatment protocol involves a course of 3–4 sessions, spaced 2–4 weeks apart. Maintenance treatments are suggested every six months. Reported outcomes include gradual, cumulative improvements over weeks to months, rather than the immediate effects seen with dermal fillers.

Clinical Experience

Following an investment of over £3,000 in advanced training courses, we conducted a trial of polynucleotide treatments on a select group of patients as well as on ourselves. Each subject received three treatments over a three-month period, adhering strictly to the recommended protocol.

The outcomes were underwhelming. Overall, we observed no significant improvement in skin quality or appearance. A mild enhancement in the under-eye area was noted, but it did not justify the cost.

Conclusion

Given the limited results and the high cost of treatment—exceeding £1,000 for a full course—we have opted not to include polynucleotides as a treatment in our clinic. In our professional opinion, the value for money is insufficient when compared to other available options.

Alternative Treatments

Dermal Fillers: Provide immediate and noticeable improvement, with results typically lasting over a year. Additionally, they are more cost-effective than polynucleotides.

Skincare Regimen: A consistent and targeted skincare routine, particularly incorporating Vitamin C and Vitamin A, can significantly enhance skin regeneration by supporting collagen and elastin production.

Click here to learn about a skin care regime that works